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The PLCRC-PROTECT study: dietary intake after colorectal cancer diagnosis in relation to treatment outcomes

Previous research has mainly focused on the relationship between diet (lifestyle) and the risk of developing colorectal cancer. For example, it is known that a Western diet - high in red meat, processed meats, alcohol, and low in vegetables and fruits - increases the risk of colorectal cancer. Further, people with an increased BMI have an increased risk of getting colorectal cancer, while those who are more physically active have a reduced risk of developing this type of tumor.

Every year, approximately 13,000 people in the Netherlands are diagnosed with colon or rectal cancer. Treatment usually includes surgery, often in combination with radiation or systemic therapy. As a result of the disease and its treatment, a loss of appetite may occur which could alter body weight. It is hypothesized that maintaining a good nutritional status after diagnosis may contribute to better treatment outcomes.

Aim

In the PROTECT study, we investigate the relationship between dietary intake after diagnosis and treatment outcomes. We try to find answers to questions as: is a change in diet and lifestyle also important after diagnosis? Can patients influence their outcomes by living healthier or eating certain foods after diagnosis? Is it good to use certain dietary supplements after diagnosis? And do these associations differ by type of colorectal cancer?

Design

For this study in 1000 recently diagnosed patients with colorectal cancer, regular PLCRC quality of life questionnaires will be complemented with specific dietary intake and dietary supplement questionnaires. Furthermore, we are interested in smell and taste experiences. With this research project we aim to provide evidence for guidelines on dietary intake after diagnosis and contribute to an optimal integration of dietary support in the multidisciplinary treatment.

PLCRC-PROTECT is initiated by the UMC Utrecht. Patients from over 20 centers in the Netherlands will be approached and asked to participate in this study.

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