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Improving clinical management of colon cancer through CONNECTION, a nationwide Colon Cancer Registry and Stratification effort

Colon cancer can be divided into four subtypes using the CMS classification. All four subtypes have different tumor cell properties. The aim of the CONNECTION-II study is to see whether there is a difference in the effect of chemotherapy between the different types of colorectal cancer. With the current knowledge, we cannot yet accurately predict which patients will actually benefit from receiving chemotherapy. The different properties of colorectal cancer at the tumor cell level may be the reason that some patients with colorectal cancer respond well to regular chemotherapy (capecitabine and oxaliplatin) and other patients less well. This study investigates whether there is a difference in the effect of chemotherapy between patients with different subtypes of colorectal cancer. We do this by giving chemotherapy before and after surgery, instead of all courses after the surgery.

Giving chemotherapy before surgery rather than after surgery provides an opportunity to study the response to chemotherapy on the tumor, that is removed during surgery. This would not be possible if we only administer the chemotherapy after surgery because then the tumor has already been removed.

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